Rebecca Ellston Selected Research

AZD8835

1/2016	Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers.
11/2015	Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.

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Rebecca Ellston Research Topics

Disease

7	Neoplasms (Cancer) 12/2017 - 01/2010
2	Breast Neoplasms (Breast Cancer) 12/2017 - 01/2016
1	Prostatic Neoplasms (Prostate Cancer) 01/2015

Drug/Important Bio-Agent (IBA)

2	AZD8186IBA 12/2017 - 01/2015
2	Biomarkers (Surrogate Marker)IBA 12/2017 - 01/2015
2	AZD8835IBA 01/2016 - 11/2015
1	Proteins (Proteins, Gene)FDA Link 12/2017
1	Protein Isoforms (Isoforms)IBA 12/2017
1	RNA (Ribonucleic Acid)IBA 12/2017
1	CholesterolIBA 12/2017
1	Antisense OligonucleotidesIBA 01/2017
1	2- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphateIBA 02/2016
1	AcidsIBA 02/2016
1	Histones (Histone)IBA 02/2016
1	ProdrugsIBA 02/2016
1	Aurora KinasesIBA 02/2016
1	AZD2811IBA 02/2016
1	Phosphotransferases (Kinase)IBA 01/2016
1	Estrogen ReceptorsIBA 01/2016
1	Docetaxel (Taxotere)FDA Link 01/2015
1	Sirolimus (Rapamycin)FDA Link 01/2010
1	(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA 01/2010
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2010

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2015